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Reply to: Can the N170 Be Used as an Electrophysiological Biomarker Indexing Face Processing Difficulties in Autism Spectrum Disorder?

Published:October 31, 2018DOI:https://doi.org/10.1016/j.bpsc.2018.09.004
      We appreciate the opportunity to further the discussion regarding the N170 in autism spectrum disorder (ASD) (
      • Kang E.
      • Keifer C.M.
      • Levy E.J.
      • Foss-Feig J.H.
      • McPartland J.C.
      • Lerner M.D.
      Atypicality of the N170 event-related potential in autism spectrum disorder: A meta-analysis.
      ). We agree that electroencephalography (EEG) holds promise for deriving biomarkers, but that such applications are not straightforward.
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      References

        • Kang E.
        • Keifer C.M.
        • Levy E.J.
        • Foss-Feig J.H.
        • McPartland J.C.
        • Lerner M.D.
        Atypicality of the N170 event-related potential in autism spectrum disorder: A meta-analysis.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2018; 3: 657-666
        • Huedo-Medina T.B.
        • Sánchez-Meca J.
        • Marín-Martínez F.
        • Botella J.
        Assessing heterogeneity in meta-analysis: Q statistic or I2 index?.
        Psychol Methods. 2006; 11: 193-206
        • Vettori S.
        • Jacques C.
        • Boets B.
        • Rossion B.
        Can the N170 be used as an electrophysiological biomarker indexing face processing difficulties in autism spectrum disorder?.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2019; 4: 321-323
        • McPartland J.C.
        Considerations in biomarker development for neurodevelopmental disorders.
        Curr Opin Neurol. 2016; 29: 118-122
        • Dawson G.
        • Jones E.J.H.
        • Merkle K.
        • Venema K.
        • Lowy R.
        • Faja S.
        • et al.
        Early behavioral intervention is associated with normalized brain activity in young children with autism.
        J Am Acad Child Adolesc Psychiatry. 2012; 51: 1150-1159
        • McPartland J.C.
        Developing clinically practicable biomarkers for autism spectrum disorder.
        J Autism Dev Disord. 2017; 47: 2935-2937
        • Hinojosa J.A.
        • Mercado F.
        • Carretié L.
        N170 sensitivity to facial expression: A meta-analysis.
        Neurosci Biobehav Rev. 2015; 55: 498-509
        • Feuerriegel D.
        • Churches O.
        • Hofmann J.
        • Keage H.A.D.
        The N170 and face perception in psychiatric and neurological disorders: A systematic review.
        Clin Neurophysiol. 2015; 126: 1141-1158
        • Sysoeva O.V.
        • Constantino J.N.
        • Anokhin A.P.
        Event-related potential (ERP) correlates of face processing in verbal children with autism spectrum disorders (ASD) and their first-degree relatives: A family study.
        Mol Autism. 2018; 9: 41
        • Taylor M.J.
        • McCarthy G.
        • Saliba E.
        • Degiovanni E.
        ERP evidence of developmental changes in processing of faces.
        Clin Neurophysiol. 1999; 110: 910-915
        • Taylor M.J.
        • Batty M.
        • Itier R.J.
        The faces of development: A review of early face processing over childhood.
        J Cogn Neurosci. 2004; 16: 1426-1442
        • Webb S.J.
        • Bernier R.
        • Henderson H.A.
        • Johnson M.H.
        • Jones E.J.
        • Lerner M.D.
        • et al.
        Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism.
        J Autism Dev Disord. 2015; 45: 425-443
        • Keil A.
        • Debener S.
        • Gratton G.
        • Junghöfer M.
        • Kappenman E.S.
        • Luck S.J.
        • et al.
        Committee report: Publication guidelines and recommendations for studies using electroencephalography and magnetoencephalography.
        Psychophysiology. 2014; 51: 1-21
        • Webb S.J.
        • Dawson G.
        • Bernier R.
        • Panagiotides H.
        ERP evidence of atypical face processing in young children with autism.
        J Autism Dev Disord. 2006; 36: 881-890
        • Ferguson C.J.
        An effect size primer: A guide for clinicians and researchers.
        Prof Psychol Res Pract. 2009; 40: 532-538
        • Sapp M.
        Confidence intervals within hypnosis research.
        Sleep Hypn. 2004; 6: 169-176
        • Dawson G.
        • Webb S.J.
        • McPartland J.C.
        Understanding the nature of face processing impairment in autism: Insights from behavioral and electrophysiological studies.
        Dev Neuropsychol. 2005; 27: 403-424
        • McPartland J.C.
        • Wu J.
        • Bailey C.A.
        • Mayes L.C.
        • Schultz R.T.
        • Klin A.
        Atypical neural specialization for social percepts in autism spectrum disorder.
        Soc Neurosci. 2011; 6: 436-451

      Linked Article

      • Can the N170 Be Used as an Electrophysiological Biomarker Indexing Face Processing Difficulties in Autism Spectrum Disorder?
        Biological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 4Issue 3
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          Difficulties in understanding facial signals of social communication, including facial identity and emotional expressions, have been hypothesized for many years in autism spectrum disorder (ASD). These difficulties are thought to impede social communication and interaction, which, in combination with a pattern of restricted and repetitive behavior and interests, constitute the core symptoms of ASD (1). Many behavioral studies have investigated face processing impairments in ASD, and recent reviews conclude that there are both quantitative and qualitative differences compared with neurotypical individuals (2,3).
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