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Dynamic Causal Modeling of Insular, Striatal, and Prefrontal Cortex Activities During a Food-Specific Go/NoGo Task

  • Qinghua He
    Correspondence
    Address correspondence to Qinghua He, Ph.D., Faculty of Psychology, Southwest University, No. 2 Tiansheng Road, Beibei, Chongqing 400715, China.
    Affiliations
    Faculty of Psychology, Southwest University, Collaborative Innovation Center of Assessment toward Basic Education Quality, Beibei, Chongqing

    Chongqing Collaborative Innovation Center for Brain Science, Collaborative Innovation Center of Assessment toward Basic Education Quality, Beibei, Chongqing

    Southwest University Branch, Collaborative Innovation Center of Assessment toward Basic Education Quality, Beibei, Chongqing
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  • Xiaolu Huang
    Affiliations
    Faculty of Psychology, Southwest University, Collaborative Innovation Center of Assessment toward Basic Education Quality, Beibei, Chongqing
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  • Shuyue Zhang
    Affiliations
    Faculty of Education, Guangxi Normal University, Guangxi Colleges and Universities Key Laboratory of Cognitive Neuroscience and Applied Psychology, Guilin, Guangxi, China
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  • Ofir Turel
    Affiliations
    Information Systems and Decision Sciences, California State University, Fullerton, California

    Brain and Creativity Institute, University of Southern California, Los Angeles, California

    Department of Psychology, University of Southern California, Los Angeles, California
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  • Liangsuo Ma
    Affiliations
    Department of Radiology, Virginia Commonwealth University, Richmond, Virginia

    Institute for Drug and Alcohol Studies, Richmond, Virginia
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  • Antoine Bechara
    Affiliations
    Brain and Creativity Institute, University of Southern California, Los Angeles, California

    Department of Psychology, University of Southern California, Los Angeles, California
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Published:December 12, 2018DOI:https://doi.org/10.1016/j.bpsc.2018.12.005

      Abstract

      Background

      This study aimed to investigate the dynamic interactions among three neural systems that are implicated in substance and behavioral addictions in response to food cues in young adults. These include an impulsive system involving the striatum, a reflective system involving the prefrontal cortex, and a homeostasis sensing system involving the insular cortex.

      Methods

      College students (N = 45) with various levels of body mass index were recruited. Functional magnetic resonance imaging data were acquired while participants performed food-related Go/NoGo tasks, with low-calorie and high-calorie food cues. Participants were scanned under both food satiety and deprivation conditions. Dynamic causal modeling was applied to the data to examine the causal architecture of coupled or distributed dynamics among the aforementioned systems.

      Results

      Participants showed difficulty inhibiting responses to high-calorie foods as suggested by higher false alarm rate and decision bias for low-calorie food Go task. This difficulty was enhanced during the food deprivation condition. Deprivation increased neural activity of both the insula and the striatum bilaterally in response to high-calorie foods during Go trials and anterior cingulate cortex and dorsolateral prefrontal cortex activity during NoGo trials. Dynamic causal modeling analysis revealed that food deprivation modulated the communications between the insula, striatum, and dorsolateral prefrontal cortex, and the modulations were positively associated with body mass index.

      Conclusions

      The results support tripartite views of decision making. Deprivation states, such as hunger, trigger insular activity, which modulates the balance between impulsive and reflective systems when facing tempting food cues.

      Keywords

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