Researchers in psychiatry are increasingly moving away from disorder-based distinctions
and toward dimensional and transdiagnostic definitions of mental health, citing rising
concerns about the validity of categorical definitions and the diminishing utility
of case-control designs. These frameworks seek to map normal variation of mental health
in the general population that does not obey traditional diagnostic boundaries and
prescribes no clear division between individuals with mental illness and healthy individuals.
While there is great enthusiasm for this initiative, questions abound. What constitutes
a transdiagnostic study? How can we advance knowledge without a standardized rubric
for defining clinical phenomena consistently across studies?
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological Psychiatry: Cognitive Neuroscience and NeuroimagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Transdiagnostic approaches to mental health problems: Current status and future directions.J Consult Clin Psychol. 2020; 88: 179-195
- Characterizing a psychiatric symptom dimension related to deficits in goal-directed control.eLife. 2016; 5e11305
- Psychiatric symptom dimensions are associated with dissociable shifts in metacognition but not task performance.Biol Psychiatry. 2018; 84: 443-451
- Incentives boost model-based control across a range of severity on several psychiatric constructs.Biol Psychiatry. 2019; 85: 425-433
- Transdiagnostic phenotyping reveals a host of metacognitive deficits implicated in compulsivity.Sci Rep. 2020; 10: 2883
- Comparison of the association between goal-directed planning and self-reported compulsivity vs obsessive-compulsive disorder diagnosis.JAMA Psychiatry. 2019; 77: 1-10
- Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits.NeuroImage. 2019; 202: 116070
- Association between a directly translated cognitive measure of negative bias and self-reported psychiatric symptoms [published online ahead of print Mar 4].Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;
- Associations between aversive learning processes and transdiagnostic psychiatric symptoms revealed by large-scale phenotyping.bioRxiv. 2019; https://doi.org/10.1101/843045
- Machine learning and big data in psychiatry: Toward clinical applications.Curr Opin Neurobiol. 2019; 55: 152-159
Article info
Publication history
Published online: April 30, 2020
Accepted:
April 27,
2020
Received:
April 12,
2020
Identification
Copyright
© 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
