Abstract
Background
Deficits in relational episodic memory encoding are characteristic of schizophrenia
(SZ), but whole-brain multivariate analyses of these deficits have been lacking. Open
science has provided task-based functional magnetic resonance imaging (fMRI) data
investigating paired associate encoding in SZ, but it has not yet been mobilized to
address this gap in the literature. Therefore, in this study, we use previously unpublished
task fMRI data to conduct the first network-level investigation of impaired relational
episodic encoding in SZ.
Methods
Using fMRI data acquired from 40 healthy control participants and 40 age- and sex-matched
persons with SZ, we examined the networks involved in successful versus unsuccessful
encoding of verbal paired associates using an associative semantic strategy.
Results
Constrained principal component analysis for fMRI revealed 3 distinct functional networks
recruited during encoding: a responding network, a linguistic processing/attention
network, and the default mode network. Relative to the healthy control group, the
SZ group exhibited aberrant activity in all 3 networks during successful encoding;
namely, hypoactivation in the linguistic processing/attention network, lower peak
activation in the responding network, and weaker suppression in the default mode network.
Independent of group effects, a pattern of stronger anticorrelating linguistic processing/attention–default
mode network activity during successful encoding significantly predicted subsequent
retrieval of paired associates.
Conclusions
Together with previous observations of language network hypoactivation during controlled
semantic processes, these results suggest that abnormalities in networks representing
language and meaning may contribute to difficulties employing deep semantic strategies
during relational episodic encoding in SZ.
Keywords
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Article info
Publication history
Published online: July 22, 2021
Accepted:
July 11,
2021
Received in revised form:
June 14,
2021
Received:
April 12,
2021
Identification
Copyright
© 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
