The Feature of Sleep Spindle Deficits in Patients With Schizophrenia With and Without Auditory Verbal Hallucinations

  • Author Footnotes
    1 J-BS and HD contributed equally to this work.
    Jin-Bo Sun
    Footnotes
    1 J-BS and HD contributed equally to this work.
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Author Footnotes
    1 J-BS and HD contributed equally to this work.
    Hui Deng
    Footnotes
    1 J-BS and HD contributed equally to this work.
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Si-Yu Wang
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Ya-Peng Cui
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Xue-Juan Yang
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Chen-Yang Wang
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Yi-Huan Chen
    Affiliations
    Department of Psychiatry, Xijing Hospital, The Air Force Medical University, Xi’an, Shaanxi, China
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  • Qun Yang
    Affiliations
    Department of Medical Psychology, The Air Force Medical University, Xi’an, Shaanxi, China
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  • Hua-Ning Wang
    Correspondence
    Hua-Ning Wang, Ph.D.
    Affiliations
    Department of Psychiatry, Xijing Hospital, The Air Force Medical University, Xi’an, Shaanxi, China
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  • Wei Qin
    Correspondence
    Address correspondence to Wei Qin, Ph.D.
    Affiliations
    Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China
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  • Author Footnotes
    1 J-BS and HD contributed equally to this work.
Published:August 08, 2021DOI:https://doi.org/10.1016/j.bpsc.2021.07.013

      Abstract

      Background

      Previous sleep electroencephalography studies have detected abnormalities in sleep architecture and sleep spindle deficits in schizophrenia (SCZ), but the consistency of these results was not robust, which might be due to the small sample size and the influence of clinical factors such as the various medication therapies and symptom heterogeneity. This study aimed to regard auditory verbal hallucinations (AVHs) as a pointcut to downscale the heterogeneity of SCZ and explore whether some sleep architecture and spindle parameters were more severely impaired in SCZ patients with AVHs compared with those without AVHs.

      Methods

      A total of 90 SCZ patients with AVHs, 92 SCZ patients without AVHs, and 91 healthy control subjects were recruited, and parameters of sleep architecture and spindle activities were compared between groups. The correlation between significant sleep parameters and clinical indicators was analyzed.

      Results

      Deficits of sleep spindle activities at prefrontal electrodes and intrahemispheric spindle coherence were observed in both AVH and non-AVH groups, several of which were more serious in the AVH group. In addition, deficits of spindle activities at central and occipital electrodes and interhemispheric spindle coherence mainly manifested accompanying AVH symptoms, most of which were retained in the medication-naive first-episode patients, and were associated with Auditory Hallucination Rating Scale scores.

      Conclusions

      Our results suggest that the underlying mechanism of spindle deficits might be different between SCZ patients with and without AVHs. In the future, the sleep feature of SCZ patients with different symptoms and the influence of clinical factors, such as medication therapy, should be further illustrated.

      Keywords

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