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Identifying Neurobiological Markers of Posttraumatic Stress Disorder Using Resting-State Functional Magnetic Resonance Imaging Data: The Promise of Data-Driven Computational Approaches

  • Yuval Neria
    Correspondence
    Address correspondence to Yuval Neria, Ph.D.
    Affiliations
    Department of Psychiatry, Columbia University Irving Medical Center, New York, New York

    The New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, New York
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  • Amit Lazarov
    Affiliations
    School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel
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  • Xi Zhu
    Affiliations
    Department of Psychiatry, Columbia University Irving Medical Center, New York, New York

    The New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, New York
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      SEE CORRESPONDING ARTICLE ON PAGE 139
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      Linked Article

      • Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach
        Biological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 7Issue 2
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          Posttraumatic stress disorder (PTSD) is a debilitating disorder, and there is no current accurate prediction of who develops it after trauma. Neurobiologically, individuals with chronic PTSD exhibit aberrant resting-state functional connectivity (rsFC) between the hippocampus and other brain regions (e.g., amygdala, prefrontal cortex, posterior cingulate), and these aberrations correlate with severity of illness. Previous small-scale research (n < 25) has also shown that hippocampal rsFC measured acutely after trauma is predictive of future severity using a region-of-interest–based approach.
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