Advertisement

Metabolic Traces in the Human Brain: Genetic Risk for Diabetes and Altered Structural Connectivity in Depression

  • Nils B. Kroemer
    Correspondence
    Address correspondence to Nils B. Kroemer, Ph.D.
    Affiliations
    Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany
    Search for articles by this author
  • Tobias Kaufmann
    Affiliations
    Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany

    Norwegian Centre for Mental Disorders Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Search for articles by this author
      SEE CORRESPONDING ARTICLE ON PAGE 333
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      References

        • Striedter G.F.
        Principles of Brain Evolution.
        Sinauer Associates, Sunderland2005
        • Kleinridders A.
        • Cai W.
        • Cappellucci L.
        • Ghazarian A.
        • Collins W.R.
        • Vienberg S.G.
        • et al.
        Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.
        Proc Natl Acad Sci U S A. 2015; 112: 3463-3468
        • Yu M.
        • Zhang X.
        • Lu F.
        • Fang L.
        Depression and risk for diabetes: A meta-analysis.
        Can J Diabetes. 2015; 39: 266-272
        • Kleinridders A.
        • Ferris H.A.
        • Cai W.
        • Kahn C.R.
        Insulin action in brain regulates systemic metabolism and brain function.
        Diabetes. 2014; 63: 2232-2243
        • Repple J.
        • König A.
        • de Lange S.C.
        • Opel N.
        • Redlich R.
        • Meinert S.
        • et al.
        Association between genetic risk for type 2 diabetes and structural brain connectivity in major depressive disorder.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2022; 7: 333-340
        • Zilliox L.A.
        • Chadrasekaran K.
        • Kwan J.Y.
        • Russell J.W.
        Diabetes and cognitive impairment.
        Curr Diab Rep. 2016; 16: 87
        • Teckentrup V.
        • Neubert S.
        • Santiago J.C.P.
        • Hallschmid M.
        • Walter M.
        • Kroemer N.B.
        Non-invasive stimulation of vagal afferents reduces gastric frequency.
        Brain Stimul. 2020; 13: 470-473
        • Arns M.
        • van Dijk H.
        • Luykx J.J.
        • van Wingen G.
        • Olbrich S.
        Stratified psychiatry: Tomorrow’s precision psychiatry?.
        Eur Neuropsychopharmacol. 2021; 55: 14-19
        • Westlye L.T.
        • Alnæs D.
        • van der Meer D.
        • Kaufmann T.
        • Andreassen O.A.
        Population-based mapping of polygenic risk for schizophrenia on the human brain: New opportunities to capture the dimensional aspects of severe mental disorders.
        Biol Psychiatry. 2019; 86: 499-501
        • Tabak A.G.
        • Herder C.
        • Rathmann W.
        • Brunner E.J.
        • Kivimaki M.
        Prediabetes: A high-risk state for diabetes development.
        Lancet. 2012; 379: 2279-2290

      Linked Article

      • Association Between Genetic Risk for Type 2 Diabetes and Structural Brain Connectivity in Major Depressive Disorder
        Biological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 7Issue 3
        • Preview
          Major depressive disorder (MDD) and type 2 diabetes mellitus (T2D) are known to share clinical comorbidity and to have genetic overlap. Besides their shared genetics, both diseases seem to be associated with alterations in brain structural connectivity and impaired cognitive performance, but little is known about the mechanisms by which genetic risk of T2D might affect brain structure and function and if they do, how these effects could contribute to the disease course of MDD.
        • Full-Text
        • PDF