Metabolic Traces in the Human Brain: Genetic Risk for Diabetes and Altered Structural Connectivity in Depression

  • Nils B. Kroemer
    Address correspondence to Nils B. Kroemer, Ph.D.
    Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany
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  • Tobias Kaufmann
    Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany

    Norwegian Centre for Mental Disorders Research, Oslo University Hospital and University of Oslo, Oslo, Norway
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      Linked Article

      • Association Between Genetic Risk for Type 2 Diabetes and Structural Brain Connectivity in Major Depressive Disorder
        Biological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 7Issue 3
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          Major depressive disorder (MDD) and type 2 diabetes mellitus (T2D) are known to share clinical comorbidity and to have genetic overlap. Besides their shared genetics, both diseases seem to be associated with alterations in brain structural connectivity and impaired cognitive performance, but little is known about the mechanisms by which genetic risk of T2D might affect brain structure and function and if they do, how these effects could contribute to the disease course of MDD.
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