Abstract
Background
The hippocampus is a core region of interest for all major mental disorders, and its
subfields implement distinctive functions. It is unclear whether the mental disorders
exhibit common patterns of hippocampal impairments, and we lack knowledge on whether
and how hippocampal subfields represent deficit spectra across mental disorders.
Methods
Using brain images of 1123 individuals scanned on a single magnetic resonance imaging
scanner, we examined the commonality, specificity, and symptom associations of the
volume of hippocampal subfields across patients with schizophrenia, patients with
obsessive-compulsive disorder, patients with bipolar disorder, patients with major
depressive disorder, and healthy control subjects. We further performed a transdiagnostic
analysis of the individual variability of the volume of hippocampal subfields to reflect
cross-disease gradients in the hippocampus.
Results
We found common and disease-specific abnormalities in a few hippocampal fields and
identified 2 reliable transdiagnostic factors in the hippocampal subfields, each reflecting
a spectrum of mental disorders. The plane spanned by the 2 most reliable factors provided
a clearer view of hippocampal volume abnormality spectra among the major mental disorders.
In addition, functional and genetic enrichment analyses supported the different roles
of the 2 hippocampal factors in mental disorders.
Conclusions
The volume of hippocampal subfields reflected some commonality and specificity among
the 3 major mental disorders. We propose a new pathophysiological dimensional view
of the hippocampus, reflecting at least 2 spectra of mental disorders, suggesting
multivariate links among the diseases. This work highlights the value of the complementary
categorical and dimensional views of the hippocampal deficits in mental disorders.
Keywords
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Article info
Publication history
Published online: July 04, 2022
Accepted:
June 22,
2022
Received in revised form:
June 19,
2022
Received:
October 10,
2021
Identification
Copyright
© 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.