ABSTRACT
Background
The hippocampus is a core region of interest for all major mental disorders, and its
subfields implement distinctive functions. It is unclear whether the mental disorders
exhibit common patterns of hippocampal impairments, and we lack knowledge on whether
and how the hippocampal subfields represent deficit spectra across mental disorders.
Methods
Using brain images of 1123 individuals scanned on a single MRI scanner, we examined
the commonality, specificity, and symptom associations of the volume of hippocampal
subfields across schizophrenia (SZ), obsessive-compulsive disorder (OCD), bipolar
disorder (BD), and major depressive disorder (MDD) patients and healthy subjects (HC).
We further performed a transdiagnostic analysis of the individual variability of the
volume of hippocampal subfields to reflect cross-disease gradients in the hippocampus.
Results
We found common and disease-specific abnormalities in a few hippocampal fields and
identified two reliable transdiagnostic factors in the hippocampal subfields, each
reflecting a spectrum of mental disorders. The plane spanned by the two most reliable
factors provided a clearer view of hippocampal volume abnormality spectra among the
major mental disorders. In addition, functional and genetic enrichment analyses supported
the different roles of the two hippocampal factors in mental disorders.
Conclusions
The volume of hippocampal subfields reflects some commonality and specificity among
the four major mental disorders. We propose a new pathophysiological dimensional view
of the hippocampus, reflecting at least two spectra of mental disorders, suggesting
multivariate links among the diseases. This work highlights the value of the complementary
categorical and dimensional view of the hippocampal deficits in mental disorders.
Keywords
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Article Info
Publication History
Accepted:
June 22,
2022
Received in revised form:
June 19,
2022
Received:
October 10,
2021
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.
