Comparative Pharmacology and Circuit-Level Models of the Effects of Psychedelic Drugs on the Human Brain

  • Frederick S. Barrett
    Address correspondence to Frederick S. Barrett, Ph.D.
    Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Department of Neuroscience, Johns Hopkins University School of Medicine, and the Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland
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        • Steeds H.
        • Carhart-Harris R.L.
        • Stone J.M.
        Drug models of schizophrenia.
        Ther Adv Psychopharmacol. 2015; 5: 43-58
        • Geyer M.A.
        • Vollenweider F.X.
        Serotonin research: Contributions to understanding psychoses.
        Trends Pharmacol Sci. 2008; 29: 445-453
        • Avram M.
        • Brandl F.
        • Knolle F.
        • Cabello J.
        • Leucht C.
        • Scherr M.
        • et al.
        Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia.
        Brain. 2020; 143: 3495-3505
        • Doss M.K.
        • Madden M.B.
        • Gaddis A.
        • Nebel M.B.
        • Griffiths R.R.
        • Mathur B.N.
        • Barrett F.S.
        Models of psychedelic drug action: Modulation of cortical-subcortical circuits.
        Brain. 2022; 145: 441-456
        • Avram M.
        • Müller F.
        • Rogg H.
        • Korda A.
        • Andreou C.
        • Holze F.
        • et al.
        Characterizing thalamocortical (dys)connectivity following d-amphetamine, LSD, and MDMA administration.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2022; 7: 885-894
        • Griffiths R.R.
        • Johnson M.W.
        • Richards W.A.
        • Richards B.D.
        • McCann U.
        • Jesse R.
        Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects.
        Psychopharmacology (Berl). 2011; 218: 649-665
        • Gaddis A.
        • Lidstone D.E.
        • Nebel M.B.
        • Griffiths R.R.
        • Mostofsky S.H.
        • Mejia A.F.
        • Barrett F.S.
        Psilocybin induces spatially constrained alterations in thalamic functional organization and connectivity.
        Neuroimage. 2022; 260: 119434
        • Barrett F.S.
        • Preller K.H.
        • Herdener M.
        • Janata P.
        • Vollenweider F.X.
        Serotonin 2A receptor signaling underlies LSD-induced alteration of the neural response to dynamic changes in music.
        Cereb Cortex. 2018; 28: 3939-3950
        • Vollenweider F.X.
        • Vontobel P.
        • Hell D.
        • Leenders K.L.
        5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man—A PET study with [11C]raclopride.
        Neuropsychopharmacology. 1999; 20: 424-433
        • McCulloch D.E.-W.
        • Knudsen G.M.
        • Barrett F.S.
        • Doss M.K.
        • Carhart-Harris R.L.
        • Rosas F.E.
        • et al.
        Psychedelic resting-state neuroimaging: A review and perspective on balancing replication and novel analyses.
        Neurosci Biobehav Rev. 2022; 138104689

      Linked Article

      • Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration
        Biological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 7Issue 9
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          Patients with psychotic disorders present alterations in thalamocortical intrinsic functional connectivity as measured by resting-state functional magnetic resonance imaging. Specifically, thalamic intrinsic functional connectivity is increased with sensorimotor cortices (hyperconnectivity) and decreased with prefrontal limbic cortices (hypoconnectivity). Psychedelics such as lysergic acid diethlyamide (LSD) elicit similar thalamocortical hyperconnectivity with sensorimotor areas in healthy volunteers.
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