Abstract
Background
Substance use disorder is conceptualized as a neuropsychiatric disease with multifaceted
phenotypic manifestations including disrupted interactions between brain networks.
While the current understanding of brain network interactions is mostly based on static
functional connectivity, accumulating evidence suggests that temporal dynamics of
these network interactions may better reflect brain function and disease-related dysfunction.
We thus investigated brain dynamics in cocaine use disorder and assessed their relationship
with cocaine dependence severity.
Methods
Using a time frame analytical approach on resting-state functional magnetic resonance
imaging data of 54 cocaine users and 54 age- and sex-matched healthy control participants,
we identified temporally recurring brain network configuration patterns, termed brain
states. With Menon’s triple network model as a guide, we characterized these state
dynamics by quantifying their occurrence rate and transition probability. Group differences
in the state dynamics and their association with cocaine dependence were assessed.
Results
Three recurrent brain states with spatial patterns resembling the default mode, salience,
and executive control networks were identified. Compared with healthy control subjects,
cocaine users showed a higher default mode state occurrence rate and higher probability
of transitioning from the salience state to the default mode state, with the former
being attributed to the latter. A composite state transition probability negatively
correlated with cocaine dependence severity.
Conclusions
Our results provide novel evidence supporting the triple network model. While confirming
hyperactivity of default mode network in cocaine users, our findings indicate the
failure of salience network in toggling between default mode and executive control
networks in cocaine use disorder.
Keywords
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Article info
Publication history
Published online: September 02, 2022
Accepted:
August 22,
2022
Received in revised form:
July 28,
2022
Received:
April 23,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
TZ and HG contributed equally to this work.
Identification
Copyright
Published by Elsevier Inc on behalf of Society of Biological Psychiatry.
