Sleep has several therapeutic and restorative roles in brain health, facilitating
memory consolidation, cognitive ability, synaptic plasticity, immune function, and
metabolic clearance of inflammatory proteins that accumulate throughout the day (
1
,
2
). Sleep problems are more than 4 times more prevalent in individuals with autism
spectrum disorder (ASD) compared with individuals without ASD (
3
) and can have adverse effects on brain development and quality of life of both the
individual and their families (
1
). While numerous studies have shown that sleep problems in ASD emerge early in life
and prevail well into adulthood, the early biological mechanisms involved remain unclear.
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References
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Article info
Publication history
Accepted:
November 3,
2022
Received:
November 2,
2022
Identification
Copyright
© 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Sleep Problems in Preschoolers With Autism Spectrum Disorder Are Associated With Sensory Sensitivities and Thalamocortical OverconnectivityBiological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 8Issue 1
- PreviewProjections between the thalamus and sensory cortices are established early in development and play an important role in regulating sleep as well as in relaying sensory information to the cortex. Atypical thalamocortical functional connectivity frequently observed in children with autism spectrum disorder (ASD) might therefore be linked to sensory and sleep problems common in ASD.
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