At a time when the pharmaceutical industry has reduced investment in the discovery of new psychotropic medications, Zhang et al. (
1) show how new approaches based on advances in brain imaging analysis methods can facilitate drug discovery. Specifically, they identify the angiotensin II type 1 receptor (AT1R) pathway as a promising novel target for the modulation of subjective fear experience in humans.
- Zhang R.
- Zhao W.
- Qi Z.
- Xu T.
- Zhou F.
- Becker B.
Angiotensin II regulates the neural expression of subjective fear in humans: A precision pharmaco-neuroimaging approach.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2023; 8: 262-270
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- Angiotensin II regulates the neural expression of subjective fear in humans: A precision pharmaco-neuroimaging approach.Biol Psychiatry Cogn Neurosci Neuroimaging. 2023; 8: 262-270
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Accepted: January 9, 2023
Received: January 7, 2023
© 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Angiotensin II Regulates the Neural Expression of Subjective Fear in Humans: A Precision Pharmaco-Neuroimaging ApproachBiological Psychiatry: Cognitive Neuroscience and NeuroimagingVol. 8Issue 3
- PreviewRodent models and pharmacological neuroimaging studies in humans have been used to test novel pharmacological agents to reduce fear. However, these strategies are limited with respect to determining process-specific effects on the actual subjective experience of fear, which represents the key symptom that motivates patients to seek treatment. In this study, we used a novel precision pharmacological functional magnetic resonance imaging approach based on process-specific neuroaffective signatures to determine effects of the selective angiotensin II type 1 receptor (AT1R) antagonist losartan on the subjective experience of fear.